Eastern equine encephalitis is a viral disease caused by an
arbovirusRead the content of the note 1
. Infected mosquitoes can spread the virus to other animals and, in rare cases, to people.
The virus that causes Eastern equine encephalitis is maintained in nature in a transmission cycle between birds and mosquitoes that act as reservoirs for the virus. In Québec, cases are typically seen from June to October.
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At-risk animals
Equids (such as horses) and humans are the species most commonly affected by Eastern equine encephalitis.
Many bird, mammal and reptile species, both domesticated and wild, can also be infected. Most will show no signs of illness.
Clinical cases of the disease have been reported in pigs, rodents and white-tailed deer.
Signs of the disease
Animals infected with Eastern equine encephalitis may show signs of the disease.
In horses
Horses that are infected may die suddenly with no clinical signs.
Early symptoms include fever and anorexia and may be followed by progressive neurological symptoms:
Depression
Lethargy, drowsiness
Hyperexcitability
Aggression
Blindness
Weakness
Paralysis of the face and/or tongue
Spinning, circling
Lack of coordination, followed by paralysis of one or more limbs
Inability to stand up, lying on its side
Convulsions
Coma
Death
Between 75% and 95% of infected horses die within two to three days after the onset of symptoms. Many survivors will exhibit residual neurological signs.
In birds
Most birds will show no clinical signs of the disease.
However, the virus can cause mortality in some species of birds such as pigeons, pheasants and emus. Symptoms may include:
Severe diarrhea
Fever
Exhaustion
Partial or total paralysis of one or both legs
Involuntary circular movements
Death
In other animals
The virus can also infect other species of animals, but the vast majority will fight off illness and show no symptoms.
Clinical signs of the disease in these other animals can be similar to those of many other diseases and include fever, weakness, lack of coordination, muscle spasms, convulsions and behavioural changes.
Transmission and incubation period
Eastern equine encephalitis is spread by the bite of a mosquito carrying the virus. Mosquitoes typically become virus carriers by feeding on infected birds, and can transmit the virus by biting birds, humans and other animals.
If an animal is infected, that can indicate that there are mosquitoes carrying the virus in the immediate environment, assuming the animal has not travelled out of the area.
In rare cases, the virus can also be spread through contact with sick or dead animals. Humans can be infected if they handle the internal organs, brain or cerebrospinal fluid of an infected animal without proper protection.
Infected horses do not develop a high enough level of virus in their bloodstream to transmit the virus to mosquitoes. This means they cannot transmit the virus to other horses around them or to humans.
Time between the virus entering the animal’s body and the appearance of symptoms
The incubation period for the disease is three to seven days.
Treatment
There is no specific treatment for infection with the Eastern equine encephalitis virus. Symptomatic treatment is used to alleviate symptoms.
Protection and prevention
Vaccination is an effective way to prevent Eastern equine encephalitis in horses. In Québec, horses must be vaccinated annually in the spring before the peak risk season, by early May at the latest. Vaccinated horses will be protected until the first hard frost. If a horse is being vaccinated for the first time, the protection period is calculated from the time it receives its booster. Always follow the manufacturer’s instructions.
Humans can contract the disease if they are bitten by a mosquito carrying the virus.
The incubation period is 4 to 10 days. Most people show no clinical signs of illness.
Some people may experience flu-like symptoms such as fever, chills and muscle aches. The illness generally lasts one to two weeks, and most people make a full recovery.
In some cases, infected people may develop meningitis or encephalitis and exhibit the following clinical signs:
Headache
Vomiting
Diarrhea
Disorientation
Convulsions
Drowsiness
Coma
Approximately one third of people who develop encephalitis die within 2 to 10 days of the onset of symptoms. Many survivors of the brain infection suffer permanent neurological damage.
In Québec, the réseau équin (French only) conducts surveillance of the Eastern equine encephalitis virus to reduce the risk of infection in horses and humans.